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Pneumocystis jirovecii is an extracellular eukaryotic organism recently shown to be related to the fungi. It is an opportunistic pathogen causing interstitial pneumonia in immunosuppressed hosts, such as premature infants, children with congenital immunodeficiencies and organ transplant recipients. With the advent of the acquired immunodeficiency syndrome, P. jirovecii pneumonia has merged as the most common life-threatening opportunistic infection in these patients. It occurs in over 75% of AIDS patients and is usually associated with diminished CD4 cell counts.
Pneumocystis jirovecii is generally confined to the lungs, although there have been recent reports of disseminated extrapulmonary disease. Symptoms include fever, non-productive coughing, and shortness of breath.
The most common form of P. jirovecii is the thick-walled cyst containing up to 8 intracystic bodies (sporozoites). These mature into extracystic pleomorphic forms, the trophozoites. The development cycle occurs in both the alveolar epithelial cells and in the alveolar spaces.
Principle of the test
The Cellabs Pneumo CEL Indirect IFA kit is an indirect immunofluorescence assay for the detection of
Pneumocystis jirovecii organisms in patient specimens (sputum or broncheoalveolar lavage).
• Superior clinical reliability
• Monoclonal antibody specific for cysts and trophozoites
• Tests slides can be interpreted in less than two minutes
• No enzyme pre-treatment required
• Simple and rapid (30 minutes incubation)
• Excellent performance on induced sputum or
Please note, the Pneumo Cel Direct IFA kit is currently unavalable - the alternative Pneumo Cel IFA Indirect Kit uses the same antibody as the Pneumo Cel Direct kit.